From 999404580aa67e12b7077e1bebeeedeab1e64403 Mon Sep 17 00:00:00 2001 From: "Jocelyn Badgley (Twipped)" Date: Wed, 5 Jan 2022 20:38:55 -0800 Subject: [PATCH] Changing disorders of sex development to differences --- public/en/chromosomes.md | 7 +++---- 1 file changed, 3 insertions(+), 4 deletions(-) diff --git a/public/en/chromosomes.md b/public/en/chromosomes.md index 454f3f8..1bb77a3 100644 --- a/public/en/chromosomes.md +++ b/public/en/chromosomes.md @@ -37,7 +37,7 @@ tweets: }!} -There are dozens of ways that chromosomes can be much more complex than XX and XY. Medically these are referred to as DSDs ([Disorders of Sex Development](https://en.wikipedia.org/wiki/Disorders_of_sex_development)). Not all result in an intersex condition, and many only manifest at the onset of puberty. +There are dozens of ways that chromosomes can be much more complex than XX and XY. Referred to as DSDs ([Differences in Sex Development](https://en.wikipedia.org/wiki/Disorders_of_sex_development)), not all of them result in an intersex condition, and many only manifest at the onset of puberty. - [De la Chapelle Syndrome](https://en.wikipedia.org/wiki/XX_male_syndrome) (46,XX Male) occurs when the SRY gene from the sperm parent crosses over into a non-Y-bearing sperm during spermatogenesis. When the egg and sperm merge, it results in an XX embryo with an SRY gene, creating a phenotypical male child with two X chromosomes. @@ -50,12 +50,11 @@ There are dozens of ways that chromosomes can be much more complex than XX and X - [XX Gonadal Dysgenesis](https://en.wikipedia.org/wiki/XX_gonadal_dysgenesis) is very similar to Swyer Syndrome, except occurs in XX children and results in nonfunctional ovaries. - - [Turner Syndrome](https://en.wikipedia.org/wiki/Turner_syndrome) (45,X) produces a phenotypically female child with numerous abnormalities. It occurs when neither an X or Y chromosome crosses over from the sperm. - [Klinefelter Syndrome](https://en.wikipedia.org/wiki/Klinefelter_syndrome) (47,XXY) results in a phenotypically male child with more feminine traits. In extremely rare cases [it appears in female assigned children](https://www.ncbi.nlm.nih.gov/pubmed/15755052) as well, resulting in feminized testicles instead of ovaries. -- [49,XXXXY Klinefelter Syndrome](https://en.wikipedia.org/wiki/49,XXXXY) is often fatal, but when it isn't, it will always results in a sterile child. +- [49,XXXXY Klinefelter Syndrome](https://en.wikipedia.org/wiki/49,XXXXY) is often fatal, but when it isn't, it often results in a sterile child. - [Trisomy X](https://en.wikipedia.org/wiki/Triple_X_syndrome) (47,XXX), [Tetrasomy X](https://en.wikipedia.org/wiki/Tetrasomy_X) (48,XXXX), and [Pentasomy X](https://en.wikipedia.org/wiki/49,_XXXXX) (49,XXXXX) all result in a female child, but with progressively more intense health issues. @@ -73,7 +72,7 @@ There are dozens of ways that chromosomes can be much more complex than XX and X - [Aromatase Deficiency](https://en.wikipedia.org/wiki/Aromatase_deficiency) causes masculinization of an otherwise female child due to excess levels of testosterone (and can bleed-over into the mother during gestation). -- [Aromatase Excess](https://en.wikipedia.org/wiki/Aromatase_excess_syndrome) causes feminization in an otherwise male child, as all testosterone is converted into estrogen. +- [Aromatase Excess](https://en.wikipedia.org/wiki/Aromatase_excess_syndrome) causes feminisation in an otherwise male child, as all testosterone is converted into estrogen. {!{
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